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Together, compensatory biceps-dominant activation and chronic supraspinatus unloading provide a mechanistic link between rotator cuff injury and sustained mitochondrial reactive oxygen species elevation, thereby facilitating activation of proteolytic and atrophy-related signaling pathways that drive progressive muscle degeneration

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doi: 10.3389/fimmu.2025.1652741 Received 24 June 2025 Accepted 11 August 2025 Published 01 September 2025 Volume 16 - 2025 Edited by Simon C