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This cytoprotective effect is mediated by PI3K and partially dependent on ERK1/2 and seems to be glucose-independent

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Importantly, previous functional studies have identified mutations in this region associated with IR phenotype ( After two years of glycemic stability, a slight worsening of metabolic control (HbA1c 7%- 53 mmol/mol) led to an increase of metformin dose (1275 mg/day) and the addition of sitagliptin (50 mg/day)