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Clinical and laboratory changes regressed after four months of drug withdrawal.7 In 1950, an adult with epilepsy was described who, after 17 days of sodium diphenylhydantoin use, developed malaise, anorexia, nausea and generalized muscle pain, and subsequently developed jaundice, fever, and a rash that progressed to pruritic exfoliative dermatitis and lymphadenopathy with abdominal pain

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As adoption and adherence grows, plan sponsors are keeping a close watch on clinical benefits and long-term financial impact