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The most recent and methodologically rigorous of them, restricted to four placebo-controlled trials in 667 patients, found no significant difference from placebo on MDS-UPDRS Part III in either the on- or off-medication state [7]

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The "maintained improvements" group (approximately 30-40% of users) reports substantial benefit retention 6-12 months post-discontinuation, typically characterized by users who completed 6+ month treatment courses using adequate concentrations (1-2% GHK-Cu), maintained consistent application patterns, addressed underlying skin damage during treatment allowing structural improvements, optimized complementary skincare including sun protection and moisturization, maintained healthy lifestyle supporting collagen synthesis including adequate protein intake and sleep, and possessed favorable genetics for collagen production and skin aging resistance