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The initial understanding of brain Se transport came from the use of 75 Se-radioactive tracer experiments ( 75 Se in the brain after the injection of labeled 75 Se-selenite to Se deficient rats was observed only after the appearance of 75 Se-Selenop in the blood plasma, differentiating the brain from other tissues ( 75 Se-labeled Selenop caused five-time higher accumulation of 75 Se in the Se-depleted rat brain 2 h later than that in Se-sufficient animals ( In recent years, our understanding of Se transport to the brain improved considerably
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