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The Phase 2 SHAPE trial (NCT04831281) in Parkinsons disease dementia and dementia with Lewy bodies failed its primary endpoint in December 2023

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This triad also shares common inflammatory pathways mediated by TLR4 activation (Zhao et al., 2021

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However, it had no significant effect on mortality rate and venous blood gases

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This finding reveals that Frizzled-7-labeled platinum-resistant cancer cells have GSH metabolic changes and also provides a breakthrough for the treatment of ovarian cancer by inducing ferroptosis

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