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In a phase 2b dose-ranging trial [FRONTIER 1 (NCT05223868)], adult participants with moderate-to-severe plaque psoriasis ( n = 255) were randomized to receive five different doses of oral icotrokinra (25 mg daily, 25 mg twice daily, 50 mg daily, 100 mg daily, or 100 mg twice daily) or placebo for 16 weeks [86]

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