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Repeatedly in these large studies, heavy metal levels were related to cardiovascular health (3, 4, 5, 6, 7, 8)

Supplementary information Supplementary Tables 15, Supplementary Figures 123 and Supplementary Methods (PDF 2144 kb) Rights and permissions About this article Cite this article Koeth, R., Wang, Z., Levison, B

Cysteine Substrate Shortage: Oxidative stress prematurely converts cysteine, the rate-limiting GSH precursor, into inactive forms

Conditional lethal AGs were identified directly from the heatmap of fitness scores, with a subset selected for further experimentation using an arbitrary fitness cutoff of ~67 ( ~ 100-fold)