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The ER is mainly expressed in female reproductive tissues, kidney, liver, bone, and white adipose tissue (Kuiper et al., 1996)

The upfront costs of GLP-1s are an ongoing concern for both public and private payers, and some employers and state Medicaid programs are now restricting coverage, despite recognizing their effectiveness at treating obesity

Because this method bypasses digestion, its often used in longevity and functional medicine clinics to reliably raise systemic levels [18]

Considering the large amount of data that is appearing at present, it is plausible that, soon, new groups of patients would benefit from the use of SGLT2 inhibitors or GLP-1-R agonists regardless of T2DM