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We observed a significant reduction in 4E-BP1 and S6K phosphorylation in both RAPTOR mutants compared with the wild type upon amino acid replenishment

Drug resistance remains one of the leading bottlenecks contributing to unsatisfactory therapeutic outcomes and eventual treatment failure during clinical cancer chemotherapy, and abundant preclinical evidence has confirmed that abnormally elevated NNMT expression is closely correlated with acquired drug resistance across various solid and hematologic malignancies

2023;15(9):e44949

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