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To further evaluate the invasion and the distribution area of RBITC-GLP-1RAs@NPs-WYRGRL in articular cartilage, RBITC-GLP-1RAs@NPs or RBITC-GLP-1RAs@NPs-WYRGRL was injected into the joint cavity, then the fluorescence intensity of articular cartilage tissue sections was observed and calculated on the first and third days (Fig