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While some studies have reported a significant association between the GSTM1 null genotype and increased CYC-related adverse effects, particularly when adjusted for clinical variables, others have found no relationship in the context of short-term high-dose regimens (Zhong et al., 2006)

Instead, it works through direct central nervous system signaling and pancreatic hormone regulation, making it pharmacologically independent of gallbladder status

In the present study, the repeated administration of cannabis for 24 days was associated with significant and dose-dependent increase in brain GSH

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