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Building on this methodology, Nakamura et al

Cross-organ communication on a metabolome level may contribute to kidney disease-associated vulnerabilities and cardiovascular disease

In the CY 2024 OPPS/ASC final rule with comment period, we estimated an ongoing annual national burden of 383,292 hours (54 hours 7,098 hospitals) and an annual national cost of $32,370,571 dollars ($4,560.52 per respondent 7,098 hospitals), which represented a $10,698,069 ($32,370,571$21,672,502) increase over our previous estimated ongoing national annual burden for subsequent years for hospitals to update their standard charge information in the CMS standard template and conform to the data dictionary

These kids tend to do well on methylcobalamin but worse on other forms, like cyanocobalamin