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Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids

Patients and methods Study design The study protocol was conducted in accordance with the Declaration of Helsinki, in compliance with the International Conference on Harmonization - Good Clinical Practice and reviewed and approved by the Institutional Review Board of Faculty of Medicine, Chulalongkorn University

Consultation Process: Initial consultations involve thorough medical reviews with board-certified physicians