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while A treatment was shown to increase Rac1 activity, the expression of constitutively active Rac1 was able to increase the production of A via increasing gamma-secretase-mediated cleavage of amyloid precursor protein (APP) (Wang et al., 2009)

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Review article: Role of glucagon-like peptide-1 receptor agonists in non-alcoholic steatohepatitis, obesity and diabetes-what hepatologists need to know