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Mechanisms Beyond Adiposity: The substantial MACE reduction not explained by weight or waist changes points to direct cardiovascular effects, including: Improved endothelial function and vascular health Anti-inflammatory pathways via central GLP-1 receptor signalling Favourable effects on blood pressure and lipid metabolism Possible early adipose tissue metabolic improvements before measurable mass reduction 3

Frequently Asked Questions Tirzepatide mimics two natural hormonesGLP-1 and GIPthat help regulate blood sugar, slow digestion, and reduce appetite

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