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The medication has been administered to millions of patients worldwide, and adverse event data shows that most side effects are temporary and manageable

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Muscle cramps during GLP-1 therapy are typically caused by indirect factors including electrolyte depletion (especially magnesium and potassium) from gastrointestinal side effects, dehydration from reduced fluid intake or vomiting/diarrhea, rapid weight loss with some lean mass reduction, and increased physical activity exceeding current conditioning levels