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For this mechanism, HSP70s recruit different co-chaperones for specific activities: e.g., in mammals, HSP40 is involved in folding, and HSP40/HSP110 are involved in refolding (Mauthe et al., 2025a

J AAPOS 12(6):591596

This dual-mechanism approach shows promise for patients with treatment-resistant diabetes and obesity but requires careful medical supervision during dose escalation