The oral tirzepatide complete guide covers what is known so far, and the comparison between tirzepatide oral versus injection helps weigh the pros and cons of each route
75,76 In another randomized controlled trial that included 180 women with PCOS and 150 without, all of whom had serum 25-OH vitamin D levels below 30 ng/mL, those with PCOS who received 20,000 IU (500 mcg) vitamin D per week experienced an improved LH:FSH 77 ratio versus placebo
Moreover, among those who have had bariatric surgery--which we now know produces comparable weight loss--their relative strength goes up and they become more physically capable.In short: There is no reason to think that GLP-1 drugs are make people relatively fatter (they reliably increase the ratio of muscle to fat), more fat than they would be doing something else (no difference), or weaker than they would be losing weight in another way.If you'd like to know more, check out my latest article
(1999) Pharmacokinetic-Pharmacodynamic Modelling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers Pharm Res 16(9):14126