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Elevated cAMP activates PKA and phosphorylates cAMP-response element binding protein (CREB), inhibiting p65/RelA and p50 activation as well as their DNA binding ability by delaying IKB- degradation and competing for the KIX binding site on CREB binding protein (90)

However, they should not be used with DPP-4 inhibitors (such as sitagliptin), and insulin or sulphonylurea doses may need adjustment to prevent hypoglycaemia

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subtilis biofilm studies, the master regulator that controls the expression of these genes, SinR, and its repressor SinI, 27 were upregulated in biofilm-associated cells