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The average area of CYP2E1 in 10 random fields (200) were analyzed

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Figure 2A outlines the upstream metabolic layer, showing how dietary pentoses, hexoses and inulin-type fructans are fermented into SCFAs (including butyrate) with concurrent reinforcement of epithelial barrier integrity, whereas Figure 2C depicts the immunological arm, in which SCFAs and related metabolites drive M2-like macrophage polarization and Treg differentiation, increase IL-10/TGF- production and thereby attenuate systemic and islet inflammation to indirectly preserve -cell function