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Cell Death Differ 2002
For example, ROS can facilitate the extrinsic apoptosis pathway through negative regulation of the cellular FLICE-inhibitory protein (Wang et al., 2008) and can induce intrinsic apoptosis pathways by triggering quick release of Cyt-c (Madesh and Hajnoczky, 2001) and regulating the Bcl-2 protein family (Burlacu, 2003)
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The 25-year follow-up of this trial found that co-supplementation with these two micronutrients actually led to small increases in risk of death from gastric cardia cancer and cancer in general, but not death from esophageal cancer (54)
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