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Deficiencies in B6, B12, and folate (B9) are common causes MTHFR gene mutations, smoking, alcohol, and sedentary behavior increase risk Certain medications and medical conditions (kidney disease, hypothyroidism, GI disorders) can elevate levels Homocysteine tends to rise with age, especially in postmenopausal women The good news: Targeted nutritional support, especially B vitamins, can usually bring homocysteine back to optimal levels

All those leads to oxidation and will lead to oxidative stress eventually

References 1 BlumWFAlherbishAAlsagheirAEl AwwaAKaplanWKoledovaEet al

The primary cause is the ROS-induced accumulation of LIP in acute myeloid leukemia cells (173)