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FIGURE 3 3.3 Nitazoxanide reduced inflammation in rats with MTX-hepatotoxicity A profound hepatic inflammation was observed in the MTX group, as demonstrated by significant augmentation in hepatic TNF-, IL-1, and IL-6 versus the CTRL group (Figures 4AC)

You may need to adjust your estrogen dose or consider alternative delivery methods (like transdermal patches or gels) that arent affected by GI absorption