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has been observed to contribute to its biological activity by scavenging free radicals and reducing oxidative stress

In some embodiments, the otic formulation or composition comprises about 0.04% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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Among these, the largest trial, REIMAGINE 2, will run for 68 weeks, including a 16-week dose escalation period followed by 52 weeks of maintenance, enrolling 2,700 T2D patients on metformin (MET), with or without SGLT-2 inhibitors