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Furthermore, GLP-1 and its analog (Ex-4) enhanced DNA repair and protected cortical neurons in brains of rats after ischemia which were due to up-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) mediated by PI3K/AKT/CREB pathway (100)

Anti-emetic medications have important restrictions: Metoclopramide should only be used for a maximum of 5 days due to neurological side effect risks Domperidone should only be used short-term at the lowest effective dose, and is contraindicated in people with certain heart conditions or taking medications that affect heart rhythm All anti-emetics have potential side effects and drug interactions that your doctor will consider If severe vomiting or dehydration occurs, seek medical review

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