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It is important to note that having potential risk factors does not preclude tirzepatide use, but rather indicates the need for patient education, appropriate monitoring during treatment initiation, and readily available emergency management resources

Without sustainable changes, like diet and exercise, weight regain and rebound effects are common, studies show

These latter AEs were more common in the anti-ActA and combination groups, and while these are difficult to assess in rodents and primates, we did not observe any of these in any of our preclinical in vivo studies

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