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While GHK-Cu is generally well-tolerated in topical research, certain contraindications or precautions should be considered, especially for systemic research or in specific populations: Systemic Research: For systemic applications, GHK-Cu is generally not recommended for subjects who are pregnant, breastfeeding, have active cancer, or suffer from Wilsons disease (a condition involving copper accumulation)

However, the peptide studied in laboratory settings is typically synthesized through peptide manufacturing processes and doesnt naturally occur in the human body

doi: 10.1016/S0140-6736(17)31363-6 2 NiccoliTPartridgeL

2 Of note, the range of reported brain GSH concentrations is extremely variable, ranging over an order of magnitude