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500,566 For example, early application of relatively mature PPMO technology showed that high doses of CPP-PMO conjugates caused kidney injury in rats

Clinica Chimica Acta

The effect of LA on attenuating fatty liver occurs earlier in animals fed a normal MCD diet than in those fed a hypercaloric MCD diet

It therefore appears that the reduction of A levels is insufficient to treat AD, and therefore calls into question the centrality of the amyloid hypothesis. Thus, we discuss the important biological functions of the A peptide, which could illuminate the less-than-satisfactory results of these anti-amyloid therapies