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In addition, activated FLSs produce large amounts of matrix metalloproteinase (MMPs) and receptor activator of nuclear factor-B ligand (RANKL), which further accelerate the degradation of intra-articular cartilage and bone tissue, leading to further bone erosion development (Ospelt et al., 2008)

cysteine as a proteinogenic amino acid and cysteine as an amino acid involved in the GSH- and thus redox- homeostasis

Secondly, the present research has not clarified how cells die during ferroptosis

In particular, a subset of inflammatory immune cells called Th17 cells are principally responsible for driving inflammation in Crohns disease, while Th2 cells drive inflammation in ulcerative colitis