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Sapindus Mukorossi Fruit Extract (Soapberry): Provides a natural, non-irritating cleanse

Because Midazolam can also impact GABA (gamma-aminobutyric acid) (12), a neurotransmitter in the brain responsible for reducing neuronal excitability throughout the nervous system, magnesium supplementation may be helpful as it supports neurotransmitter balance and muscle relaxation (13)

2020, doi: 10.1016/S2213-8587(19)30382-1

Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap