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Results Human BBB co-culture model In this study, a stem cell-derived human BBB model was used

It is being evaluated in Phase 3 trials, the first of which (SYNCHRONIZE-1, in obesity) reported positive topline results in 2026

Pyridinoline (PYD) collagen crosslinks are formed during the extracellular maturation of fibrillar collagens and released into the bloodstream as mature collagens degrade and are considered bone resorption markers (Kuo & Chen 2017)

Although rare, with an estimated prevalence of only 1 in 1,240,710 individuals (74), approximately 30% (75) of patients with ADSL deficiency exhibit autistic features along with other findings like developmental delay, encephalopathy, seizures, and growth retardation