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Other ingredients: excipient: manitol

Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication

Comment: While many commenters indicated that our proposed changes to the HPT requirements outlined in the CY 2026 OPPS/ASC proposed rule and/or the HPT requirements in general are burdensome, as discussed in prior sections of this final rule with comment period, only several commenters commented on our specific burden estimates for these information collections

Furthermore, while enzymatic removal of the L585 residue decreased FcRn binding for fusion designs with WT albumin, this was not the case for the corresponding QMP-engineered variants