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The end of PBMs is not exactly nigh, both because they are still so heavily involved in the sale of branded drugs and because operations like Cubans remain small relative to the size of the industry

Pregnancy and breastfeeding: These medications are not recommended for use during pregnancy or breastfeeding when prescribed for weight management

Thus, a limitation of ethnicity and a potential commercial bias could not be excluded in the study

the rest is mechanistic reasoning that a clinician should weigh individually: Known copper or peptide allergy the most concrete contraindication, explicit enough that clinical researchers screen it out (NCT07437586)