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Neither medication significantly affects the hepatic cytochrome P450 enzyme system in a way that would alter the metabolism of the other, and they are not known to compete for the same receptors or transport proteins

Consequently, GLP-1 RAs were recognized by Science as the top scientific breakthrough in 2023, highlighting their current and future significance as a research hotspot 10

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Patients typically experience an improvement in PASI scores as early as 4 weeks, with sustained efficacy throughout the treatment period (Singh & Argez 2018)