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For example in SUSTAIN-1, patients treated with higher dose SEM had shorter duration of the disease (mean of 3.65 years in the SEM 1 mg group compared with 4.85 years in the SEM 0.5 mg group)

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However, the majority of neuronal CB 1 Rs are found on pre-synaptic terminals, where their primary function is to suppress the release of neurotransmitters, altering the activation of post-synaptic channels and, therefore, modulating synaptic activity and plasticity (Mackie and Hille, 1992