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Use of Ibuprofen may blunt the CV effects of several therapeutic agents used to treat these medical conditions [e.g., diuretics, ACE inhibitors, or angiotensin receptor blockers (ARBs)] [See Drug Interactions]

Economy / productivity: It is estimated that the cost to the economy is around 27.6 billion each year in terms of lost productivity (people who are economically inactive due to smoking-related illnesses, people who die prematurely due to smoking-related illnesses, lost productivity through smoking-related absenteeism and smoking breaks, and reduced gross value added (GVA) due to expenditure on tobacco)

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"This is largely a margin-related increase," said Martin Feldman, tobacco analyst at Salomon Smith Barney Inc